Difference between revisions of "2020-2021 AMS-532 Fall-Spring"

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| 2020.09.23 Wed || Stepanenko, Darya || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.09.23 Wed || Stepanenko, Darya || -- || -- || Pabis et al; Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms. ''PNAS'' '''2020''', ''117'', 7200-7207.
 
|-
 
|-
  
| 2020.09.30 Wed || Samoilova, Khristina || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.09.30 Wed || Samoilova, Khristina || -- || -- || Babadi et al; Sparseness and Expansion in Sensory Representations. ''Neuron'' '''2014''', ''83'', 1-14.
 
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|-
  
| 2020.10.07 Wed || Foran, Chris || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.10.07 Wed || Foran, Chris || -- || -- || Cloutier et al; Machine Learning Models of Antibody−Excipient Preferential Interactions for Use in Computational Formulation Design. ''Mol. Pharmaceutics'' '''2020''', ''17'', 3589-3599.
 
|-
 
|-
  
| 2020.10.14 Wed || Steier, Joshua || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.10.14 Wed || Steier, Joshua || -- || -- || Zhang et al; A Structured Table of Graphs with Symmetries and Other Special Propertiess. ''Symmetry'' '''2020''', ''12'', 2.
 
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|-
  
| 2020.10.21 Wed || Hall, Carole || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.10.21 Wed || Hall, Carole || -- || -- || Ferreira et al; Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan. ''Scientific Reports'' '''2018''', ''8'', 05031.
 
|-
 
|-
  
| 2020.10.28 Wed || Chung, So Young || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.10.28 Wed || Chung, So Young || -- || -- || Kursa et al; Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model. ''J Theoretical Biology'' '''2020''', ''498'', 110295.
 
|-
 
|-
  
| 2020.11.04 Wed || Rajesh, Chandana || -- || -- || Ekeberg; Improved contact predictions in proteins: Using pseudolikelihoods to infer Potts models. ''Phys Rev E'' '''2013''', ''87'', 012707.
+
| 2020.11.04 Wed || Rajesh, Chandana || -- || -- || Shaytan et al; Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomic Insights into Nucleosome Functions. ''J Mol Biol'' '''2016''', '428'', 221-237.
 
|-
 
|-
  
| 2020.11.11 Wed || Last, First and Last, First|| -- || -- || Research Presentation
+
| 2020.11.11 Wed || Stepanenko, Darya and Samoilova, Khristina || -- || -- || Research Presentation
 
|-
 
|-
  
| 2020.11.18 Wed || Last, First and Last, First || -- || -- || Lab Rotation Presentations
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| 2020.11.18 Wed || Steier, Joshua and Rajesh, Chandana  || -- || -- || Lab Rotation Presentations
 
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| 2020.12.02 Wed || Last, First and Last, First || -- || -- || Lab Rotation Presentations
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| 2020.12.02 Wed || Chung, So Young  and Hall, Carole and Foran, Chris || -- || -- || Lab Rotation Presentations
 
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| '''Rotations or Research Group'''
 
| '''Rotations or Research Group'''
 
| '''Topic'''
 
| '''Topic'''
| '''References
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| '''This semester (Spring 2021) students will take RCR training under AMS-500 and follow that schedule:'''
SEMESTER STARTS WITH RESPONSIBLE CONDUCT OF RESEARCH'''
+
https://www.stonybrook.edu/commcms/ams/graduate/_courses/ams500
 
|-
 
|-
| 2021.01.27 Wed || Class discussion || Responsible Conduct of Research (RCR) || (1) Course Overview: Fulfilling Responsible Conduct in Research Training ||
 
  
Discussion of Overall Course Requirements which include:
 
*View the Responsible Conduct of Research and Scholarship Presentation given to department chairs by professor Michael Hadjiargyrou (to be done as a group today) [http://ringo.ams.sunysb.edu/~rizzo/StonyBrook/teaching/AMS532_AMS535_AMS536/2012-2011_AMS532_Fall_and_Spring/2010.06.08_hadjiargyrou.pdf 2010.06.08_hadjiargyrou.pdf]
 
*Complete a relevant RCR module, and achieve a 80% or higher quiz grade, within the web-based Collaborative Institutional Training Initiative located at http://www.citiprogram.org
 
*Following the schedule below and prior to coming to each class: (i) view the appropriate online lecture, (ii) read additional accompanying materials, and (iii) come prepared for the days discussion topics
 
|-
 
 
| 2021.02.03 Wed || Class discussion|| Responsible Conduct of Research (RCR) || (2) Integrity in Scholarship (Introduction to Ethics and Science) ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?time_continue=1&v=av3P2n8t2qc&feature=emb_logo Peter Williams Lecture]
 
 
 
Readings (Nature articles)
 
*[http://www.nature.com/nature/journal/v445/n7125/pdf/445240a.pdf Article 1]
 
*[http://www.nature.com/nature/journal/v445/n7125/pdf/445242a.pdf Article 2]
 
*[http://www.nature.com/nature/journal/v445/n7125/pdf/445244a.pdf Article 3]
 
 
 
Discussion
 
*Why is the class important?
 
*How should we behave as scientists?
 
*How is science a social enterprise?
 
|-
 
 
| 2021.02.10 Wed || Class discussion  || Responsible Conduct of Research (RCR) || (3) Scientific Misconduct ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=RayszjsMDH8&feature=emb_logo Michael Hadjiargyrou Lecture]
 
 
 
Reading
 
*[http://ccnmtl.columbia.edu/projects/rcr/rcr_misconduct/case/index.html#1 Introduction and Case Study 1 Sections from Columbia University online RCR Website: Research Misconduct]
 
 
 
Discussion
 
*From Case Study 1: Was it appropriate for Dr. Chan to promise Samantha second authorship based on performing some assays?
 
*From Case Study 1: It seems clear that there is a problem with Samantha's data. What should Julio do now?
 
*Why do people commit scientific misconduct?
 
*What are some consequences of committing scientific misconduct?
 
*Who are some of your mentors?
 
|-
 
 
| 2021.02.17 Wed || Class discussion || Responsible Conduct of Research (RCR) || (4) Mentoring ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=ko-PWjRyLEU&feature=emb_logo Clinton Rubin Lecture]
 
 
 
Readings
 
*[http://ccnmtl.columbia.edu/projects/rcr/rcr_mentoring Read Introduction and Case Study 1 Sections from Columbia University online RCR Website: Mentoring]
 
 
 
Discussion
 
*What qualities do you want in a mentor?
 
*What are the challenges associated with being a mentor?
 
*What does Professor Rubin mean when he says it is very important not to burn bridges?
 
*What were the problems Susan encountered with Dr. Michaels and what are some steps she could have taken to mitigate the issues?
 
|-
 
 
| 2021.02.24 Wed || Class discussion || Responsible Conduct of Research (RCR) || (5) Ownership and Authorship ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=7TPqqGWKjsg&feature=emb_logo Peter Gergen Lecture]
 
 
 
Readings
 
*[http://ccnmtl.columbia.edu/projects/rcr/rcr_authorship Read Introduction and Case Study 1 Sections from Columbia University online RCR Website: Responsible Authorship and Peer Review]
 
 
 
Discussion (also from the above Columbia course)
 
*Is it ever appropriate for authorship to change during a project or potential paper?
 
*How should authorship roles be defined?
 
*What are some abuses of authorship?
 
*Describe methods/techniques you can use to be sure you are properly citing the work of others in the context of writing a paper?
 
*Did Ms. Jacobs handle the proposed changes to authorship appropriately?
 
*Why are acknowledgments so important?
 
|-
 
 
| 2021.03.03 Wed || Class discussion || Responsible Conduct of Research (RCR) || (6) Plagiarism ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=wrokaKkeCw4&feature=emb_logo Richard Clark Lecture]
 
 
 
Readings
 
*[http://www.stonybrook.edu/uaa/academicjudiciary/policies.shtml Stony Brook's Policy on Academic Dishonesty]
 
 
 
Discussion
 
*Is plagiarism really that bad?
 
*If you copy a paragraph from another sources and modify it by say 10% is that enough to not be plagiarism ? What about 20%, or 30%, or 51% ? At what percentage is it no longer plagiarism?  How many words do you need to change?
 
|-
 
 
| 2021.03.10 Wed || Class discussion || Responsible Conduct of Research (RCR) || (7) Data Management ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=sIUkSVJEMus&feature=emb_logo Stefan Judex Lecture]
 
 
 
Readings
 
*[http://ccnmtl.columbia.edu/projects/rcr/rcr_data Read Introduction and Case Study 1 and 2 Sections from Columbia University online RCR Website: Data Acquisition and Management]
 
 
 
Discussion
 
*From Case Study 1: Why shouldn't Renee be able to use the samples since she is not studying any disease associated with the samples?
 
*From Case Study 2: Under what condition is copying allowed?
 
*Discuss ways to keep good records so that future researchers will be able to (A) reproduce your work and (B) re-analyze your results.  Include in your discussion how you you will be able to share "raw" results.
 
*How many years past a publication, if asked, should a researcher be able provide "raw data"? 
 
|-
 
| 2021.03.17 Wed || -- || -- || -- || SPRING BREAK
 
|-
 
| 2021.03.24 Wed || Class discussion || Responsible Conduct of Research (RCR) || (8) Journalism and Science ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=q5j_vqa-OI8&feature=emb_logo Howard Schneider Lecture]
 
 
 
Readings (3 Case Studies)
 
*[http://ringo.ams.sunysb.edu/~rizzo/StonyBrook/teaching/AMS532_AMS535_AMS536/2014-2013_AMS531_AMS532_Fall_and_Spring/scientists_and_reporters.pdf Scientist and Reporters handout]
 
 
 
Discussion
 
*From Case Study 1: A reporter from a major newspaper is scheduled to do a story on a drug which you think might be causing premature death among second generation mice. Do you call the reporter and disclose your concerns? Why?
 
*From Case Study 2: Your adviser says that any disclosure of her secrete research o Anthrax would be illegal? What do you do? Why?
 
*From Case Study 3: What do you do when you find out that there might be an undercover reporter working secretly to uncover the truth in an apparently poorly run hospital which might violate patients privacy? 
 
|-
 
 
| 2021.03.31 Wed || Class discussion || Responsible Conduct of Research (RCR) || (9) Responsible Conduct of Research Involving Human Subjects ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=Fa_Z9EMZzHc&feature=emb_logo Judy Matuk Lecture]
 
 
 
Readings: (Background Information, Case Studies, Helsinki Manuscript)
 
*[http://ringo.ams.sunysb.edu/~rizzo/StonyBrook/teaching/AMS532_AMS535_AMS536/2014-2013_AMS531_AMS532_Fall_and_Spring/Human_subjects.pdf Human Subjects handout]
 
*[http://ringo.ams.sunysb.edu/~rizzo/StonyBrook/teaching/AMS532_AMS535_AMS536/2014-2013_AMS531_AMS532_Fall_and_Spring/helsinki.pdf Helsinki manuscript]
 
 
Discussion
 
*From Human Subjects handout, Case Study 1: Was this an ethical trial? If so, why? If not, why not?
 
*From Human Subjects handout, Case Study 2: Was this an ethical trial? If so, why? If not, why not? Why does the Helsinki Declaration limit the use of Placebo's?
 
*From Helsinki Manuscript: Do you agree with the authors that placebo-controlled trial are in many cases necessary ?  Why ?
 
|-
 
 
| 2021.04.07 Wed || Class discussion || Responsible Conduct of Research (RCR) || (10) Responsible Conduct of Research Involving Laboratory Animals ||
 
Stony Brook Lecture
 
*[https://www.youtube.com/watch?v=9e4DcQDXvlY&feature=emb_logo Tom Zimmerman Lecture]
 
 
 
Readings (Case Studies)
 
*[http://ringo.ams.sunysb.edu/~rizzo/StonyBrook/teaching/AMS532_AMS535_AMS536/2014-2013_AMS531_AMS532_Fall_and_Spring/Animal_subjects.pdf Animal Subjects handout]
 
 
 
 
Discussion
 
*From Case Study 1: What are some of the troublesome issues associated with this set of experiments?
 
*From Case Study 1: Does giving an animal a fatal infection constitute cruelty, especially considering the characteristics of HIV infection in humans?
 
*From Case Study 1: Is it ethically appropriate to transmit intentionally a human virus in a setting that is not fully controlled?
 
*From Case Study 1: If Edith were to respond that the study could not be carried out in chimpanzees, how might it be designed instead for human subjects?
 
*What are some advantages of using Animals in experiments?
 
*Discuss the three R's?
 
*Is our class for or against Animal testing?
 
|-
 
| 2021.04.14 Wed || -- || -- || -- || ROTATION/RESEARCH PRESENTATIONS
 
|-
 
| 2021.04.21 Wed || -- || -- || -- || ROTATION/RESEARCH PRESENTATIONS
 
|-
 
| 2021.04.28 Wed || -- || -- || -- || ROTATION/RESEARCH PRESENTATIONS
 
|-
 
| 2021.05.05 Wed || -- || -- || -- || ROTATION/RESEARCH PRESENTATIONS
 
|-
 
 
|}
 
|}
  

Latest revision as of 13:49, 5 November 2020

Please see http://ringo.ams.sunysb.edu/~rizzo for Rizzo Group Homepage


Instructor Dr. Robert C. Rizzo [631-632-9340, rizzorc -at- gmail (dot) com]
Course No. AMS-532
Location/Time online, Wed 11:45PM - 12:40PM
Office Hours Anytime or by appointment, Room 1-111, Dept. of Applied Math & Statistics


GENERAL INFORMATION: GENERAL INFORMATION: AMS-532 is a two semester course in which students attend and actively participate in research discussions at weekly Journal Club meetings on topics from the current literature using the skills and knowledge acquired during laboratory rotations (AMS-531), or, if they have already joined a research lab, on topics relevant to their own research projects. In the Spring, a new component is added which is devoted to Responsible Conduct of Research (RCR) training as mandated by the University and Federal funding agencies (e.g. NIH, NSF, DOE, DOD). Note that Journal Club and Responsible Conduct of Research are required of all PhD and Masters students.


Learning Objectives:

  • (1) Actively participate in Journal Club discussions on Computationally Biology literature.
  • (2) Hone critical reading skills and lead discussions on literature related to Laboratory Rotations (AMS-531).
  • (3) Give oral presentations on specific rotation projects performed during Laboratory Rotations (AMS-531).
  • (4) Gain training in responsible conduct of research (RCR), as mandated by the university and federal funding agencies (e.g. NIH, NSF, DOE, DOD), arranged in the following sections:
    • (i) Course Overview: Fulfilling Responsible Conduct in Research Training
    • (ii) Integrity in Scholarship
    • (iii) Scientific Misconduct
    • (iv) Mentoring
    • (v) Ownership and Authorship
    • (vi) Plagiarism
    • (vii) Data Management
    • (viii) Journalism and Science
    • (ix) Responsible Conduct of Research Involving Human Subjects
    • (x) Responsible Conduct of Research Involving Laboratory Animals


(1) Journal Club: The goal of the "Journal Club" portion of AMS-532 is for students to hone critical reading and analytic skills through group discussion of literature related to lab rotation research programs. Participants take turn being "discussion leader" who informally guides the group through a manuscript for which all Journal Club members will have read in advance of the meeting. Normally, research papers are suggested by the PI of the laboratory hosting the student. An interactive WIKI page is maintained at http://ringo.ams.sunysb.edu/index.php which list papers covered to date in Journal Club along with a Course Schedule listing each week's discussion leader.


(2) Responsible Conduct of Research (RCR): The first ten Journal Club meetings in the Spring are devoted to training in "Responsible Conduct of Research" arranged in the following sections: (1) Course Overview: Fulfilling Responsible Conduct in Research Training, (2) Integrity in Scholarship, (3) Scientific Misconduct, (4) Mentoring, (5) Ownership and Authorship, (6) Plagiarism, (7) Data Management, (8) Journalism and Science, (9) Responsible Conduct of Research Involving Human Subjects, and (10) Responsible Conduct of Research Involving Laboratory Animals. Prior to each meeting, students will view online lectures by Stony Brook faculty and read additional relevant materials, which often include case studies. The RCR meetings will be run as small group breakout sessions followed by group discussion. To fully fulfill RCR training, students must also complete a relevant RCR module, and achieve a passing grade of at least 80% on subsequent quizzes, within the web-based Collaborative Institutional Training Initiative (CITI) located at www.citiprogram.org. See Course Schedule at the bottom of the WIKI page ( http://ringo.ams.sunysb.edu/index.php ) for more information including relevant links, topics, and dates for RCR meetings.


LITERATURE DISCLAIMER: Hyperlinks and manuscripts accessed through Stony Brook University's electronic journal subscriptions are provided below for educational purposes only.


PRESENTATION DISCLAIMER: Presentations may contain slides from a variety of online sources for educational and illustrative purposes only, and use here does not imply that the presenter is claiming that the contents are their own original work or research.


Journal Club Schedule (Fall & Spring) and Responsible Conduct of Research Schedule (Spring)

2020 Fall Participant Rotations or Research Group Topic References

REFERENCES SHOULD USE J. AM. CHEM. SOC. FORMAT

2020.08.26 Wed -- -- -- First year students will attend the AMS-539 ZOOM meeting
2020.09.02 Wed -- -- -- First year students will attend the AMS-539 ZOOM meeting
2020.09.09 Wed -- -- -- Faculty Research Presentations

Rizzo, Robert (11:45-12:05) Koo, Peter (12:10-12:40)

2020.09.16 Wed -- -- -- Organizational Meeting (First regular day of Journal Club).
2020.09.23 Wed Stepanenko, Darya -- -- Pabis et al; Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms. PNAS 2020, 117, 7200-7207.
2020.09.30 Wed Samoilova, Khristina -- -- Babadi et al; Sparseness and Expansion in Sensory Representations. Neuron 2014, 83, 1-14.
2020.10.07 Wed Foran, Chris -- -- Cloutier et al; Machine Learning Models of Antibody−Excipient Preferential Interactions for Use in Computational Formulation Design. Mol. Pharmaceutics 2020, 17, 3589-3599.
2020.10.14 Wed Steier, Joshua -- -- Zhang et al; A Structured Table of Graphs with Symmetries and Other Special Propertiess. Symmetry 2020, 12, 2.
2020.10.21 Wed Hall, Carole -- -- Ferreira et al; Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan. Scientific Reports 2018, 8, 05031.
2020.10.28 Wed Chung, So Young -- -- Kursa et al; Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model. J Theoretical Biology 2020, 498, 110295.
2020.11.04 Wed Rajesh, Chandana -- -- Shaytan et al; Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomic Insights into Nucleosome Functions. J Mol Biol 2016, '428, 221-237.
2020.11.11 Wed Stepanenko, Darya and Samoilova, Khristina -- -- Research Presentation
2020.11.18 Wed Steier, Joshua and Rajesh, Chandana -- -- Lab Rotation Presentations
2020.11.25 Wed -- -- -- THANKSGIVING BREAK
2020.12.02 Wed Chung, So Young and Hall, Carole and Foran, Chris -- -- Lab Rotation Presentations
2021 Spring Participant Rotations or Research Group Topic This semester (Spring 2021) students will take RCR training under AMS-500 and follow that schedule:

https://www.stonybrook.edu/commcms/ams/graduate/_courses/ams500


Required Syllabi Statements:

The University Senate Undergraduate and Graduate Councils have authorized that the following required statements appear in all teaching syllabi (graduate and undergraduate courses) on the Stony Brook Campus.. This information is also located on the Provost’s website: https://www.stonybrook.edu/commcms/provost/faculty/handbook/academic_policies/syllabus_statement.php


Student Accessibility Support Center Statement: If you have a physical, psychological, medical, or learning disability that may impact your course work, please contact the Student Accessibility Support Center, 128 ECC Building, (631) 632-6748, or at sasc@stonybrook.edu. They will determine with you what accommodations are necessary and appropriate. All information and documentation is confidential. Students who require assistance during emergency evacuation are encouraged to discuss their needs with their professors and the Student Accessibility Support Center. For procedures and information go to the following website: https://ehs.stonybrook.edu/programs/fire-safety/emergency-evacuation/evacuation-guide-people-physical-disabilities and search Fire Safety and Evacuation and Disabilities.


Academic Integrity Statement: Each student must pursue his or her academic goals honestly and be personally accountable for all submitted work. Representing another person's work as your own is always wrong. Faculty is required to report any suspected instances of academic dishonesty to the Academic Judiciary. Faculty in the Health Sciences Center (School of Health Technology & Management, Nursing, Social Welfare, Dental Medicine) and School of Medicine are required to follow their school-specific procedures. For more comprehensive information on academic integrity, including categories of academic dishonesty please refer to the academic judiciary website at http://www.stonybrook.edu/commcms/academic_integrity/index.html


Critical Incident Management: Stony Brook University expects students to respect the rights, privileges, and property of other people. Faculty are required to report to the Office of University Community Standards any disruptive behavior that interrupts their ability to teach, compromises the safety of the learning environment, or inhibits students' ability to learn. Faculty in the HSC Schools and the School of Medicine are required to follow their school-specific procedures. Further information about most academic matters can be found in the Undergraduate Bulletin, the Undergraduate Class Schedule, and the Faculty-Employee Handbook.