2014-2015 AMS-532 Fall-Spring

Please see http://ringo.ams.sunysb.edu/~rizzo for Rizzo Group Homepage

Instructor	Dr. Robert C. Rizzo [631-632-9340, rizzorc@gmail.com]
Course No.	AMS-532
Location/Time	Physics P124 Wed 12:00PM - 12:53PM
Office Hours	Anytime or by appointment, Room 1-111, Dept. of Applied Math & Statistics

Journal Club Schedule (Fall & Spring) and Responsible Conduct of Research Schedule (Spring)

2014 Fall	Participant	Rotations or Research Group	Topic	References REFERENCES SHOULD USE J. AM. CHEM. SOC. FORMAT
2014.08.27 Wed	Last name, First name	--	Topic	Organizational Meeting
2014.09.03 Wed	Kennedy, Chelsea	Green	topic	Alberts, B. et al. Rescuing US biomedical research from its systemic flaws. PNAS. 2014 March. 111(16). 5773-5777.
2014.09.10 Wed	Zou, Junjie	Raleigh	topic	Xiao, S. et al. Rational modification of protein stability by targeting surface sites leads to complicated results. PNAS. 2013 July. 110(28). 11337-11342
2014.09.17 Wed	-	--	--	AMS party
2014.09.24 Wed	Yu, Bihau	Vageli	topic	Munson, P. J. and Singh, P. K. Statistical significance of hierarchical multi-body potentials based on Delaunay tessellation and their application in sequence-structure alignment. Protein Science. 1997 March. 6. 1467-1481
2014.10.01 Wed	Santos, Ruda	Green	topic	Fujimoto, Y. K. et al. Computational models explain the oligosaccharide specificity of cyanovirin-N. Protein Science. 2008 July. 17. 2008-2014
2014.10.08 Wed	Cortes, Michael	Rizzo	topic	Jiang, M. et al. A combined experimental and computational study of Vam3, a derivative of resveratrol, and syk interaction. Int. J. Mol. Sci. 2014 September. 15. 17188-17203
2014.10.15 Wed	Belfon, Kellon	Simmerling	topic	Nguyen, H. et al. Folding simulations for proteins with diverse topologies are accessible in days with a physics-based force field and implicit solvent. JACS. 2014 September. 136. 13959-13962
2014.10.22 Wed	Hassan, Mosserval	Seeliger	topic	Rezai, T. et al. Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides. JACS. 2006 May. 128. 14073-14080
2014.10.29 Wed	Lee, Stella	Levy	topic	Tarassov, K. et al. An in vivo map of the yeast protein interactome. Science. 2008 June. 320. 1465-1470
2014.11.05 Wed	Tian, Chuan	Dill	topic	Dominguez, C. et al. HADDOCK: a protein-protein docking approach based on biochemical or biophysical information. JACS. 2013 May. 125. 1731-1737
2014.11.12 Wed	Elkin, Rena	MacCarthy	topic	Payne, J. L. and Wagner, A. The robustness and evolvability of transcription factor binding sites. Science. 2014 February. 343. 875-877
2014.11.19 Wed	Sam-Ang, Panu	Balazsi	topic	Nevozhay. D. et al. Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. PNAS. 2009 March. 106(13). 5123-5128
2014.11.26 Wed	-	--	--	THANKSGIVING BREAK
2015 Spring	Participant	Rotations or Research Group	Topic	References SEMESTER STARTS WITH RESPONSIBLE CONDUCT OF RESEARCH
2015.01.28 Wed	--	SNOW DAY	SNOW DAY	SNOW DAY
2015.02.04 Wed	Class discussion	Responsible Conduct of Research (RCR)	(1) Course Overview: Fulfilling Responsible Conduct in Research Training	Discussion of Overall Course Requirements which include: View the Responsible Conduct of Research and Scholarship Presentation given to department chairs by professor Michael Hadjiargyrou (to be done as a group today) 2010.06.08_hadjiargyrou.pdf Complete a relevant RCR module, and achieve a 80% or higher quiz grade, within the web-based Collaborative Institutional Training Initiative located at http://www.citiprogram.org Following the schedule below and prior to coming to each class: (i) view the appropriate online lecture, (ii) read additional accompanying materials, and (iii) come prepared for the days discussion topics
2015.02.11 Wed	Class discussion	Responsible Conduct of Research (RCR)	(2) Integrity in Scholarship (Introduction to Ethics and Science)	Stony Brook Lecture Peter Williams Lecture Readings (Nature articles) Article 1 Article 2 Article 3 Discussion Why is the class important? How should we behave as scientists? How is science a social enterprise?
2015.02.18 Wed	Class discussion	Responsible Conduct of Research (RCR)	(3) Scientific Misconduct	Stony Brook Lecture Michael Hadjiargyrou Lecture Reading Introduction and Case Study 1 Sections from Columbia University online RCR Website: Research Misconduct Discussion From Case Study 1: Was it appropriate for Dr. Chan to promise Samantha second authorship based on performing some assays? From Case Study 1: It seems clear that there is a problem with Samantha's data. What should Julio do now? How can the pressure to publish influence the conduct of research?
2015.02.25 Wed	Class discussion	Responsible Conduct of Research (RCR)	(4) Mentoring	Stony Brook Lecture Clinton Rubin Lecture Readings Read Introduction and Case Study 1 Sections from Columbia University online RCR Website: Mentoring Discussion What qualities do you want in a mentor? What are the challenges associated with being a mentor? What does Professor Rubin mean when he says it is very important not to burn bridges?
2015.03.04 Wed	Class discussion	Responsible Conduct of Research (RCR)	(5) Ownership and Authorship	Stony Brook Lecture Peter Gergen Lecture Readings Read Introduction and Case Study 1 Sections from Columbia University online RCR Website: Responsible Authorship and Peer Review Discussion (also from the above Columbia course) Is it ever appropriate for authorship to change during a project or potential paper? Describe methods/techniques you can use to be sure you are properly citing the work of others in the context of writing a paper? Did Ms. Jacobs handle the proposed changes to authorship appropriately?
2015.03.11 Wed	Class discussion	Responsible Conduct of Research (RCR)	(6) Plagiarism	Stony Brook Lecture Richard Clark Lecture Readings Stony Brook's Policy on Academic Dishonesty Discussion Is plagiarism really that bad? If you copy a paragraph from another sources and modify it by say 10% is that enough to not be plagiarism ? What about 20%, or 30%, or 51% ? At what percentage is it no longer plagiarism? How many words do you need to change?
2015.03.18 Wed	--	--	--	SPRING BREAK
2015.03.25 Wed	Class discussion	Responsible Conduct of Research (RCR)	(7) Data Management	Stony Brook Lecture Stefan Judex Lecture Readings Read Introduction and Case Study 1 and 2 Sections from Columbia University online RCR Website: Data Acquisition and Management Discussion From Case Study 1: Why shouldn't Renee be able to use the samples since she is not studying any disease associated with the samples? From Case Study 2: Under what condition is copying allowed? Discuss ways to keep good records so that future researchers will be able to (A) reproduce your work and (B) re-analyze your results. Include in your discussion how you you will be able to share "raw" results. How many years past a publication, if asked, should a researcher be able provide "raw data"?
2015.04.01 Wed	Class discussion	Responsible Conduct of Research (RCR)	(8) Journalism and Science	Stony Brook Lecture Howard Schneider Lecture Readings (3 Case Studies) Scientist and Reporters handout Discussion From Case Study 1: A reporter from a major newspaper is scheduled to do a story on a drug which you think might be causing premature death among second generation mice. Do you call the reporter and disclose your concerns? Why? From Case Study 2: Your adviser says that any disclosure of her secrete research o Anthrax would be illegal? What do you do? Why? From Case Study 3: What do you do when you find out that there might be an undercover reporter working secretly to uncover the truth in an apparently poorly hospital which might violate patients privacy?
2015.04.08 Wed	Class discussion	Responsible Conduct of Research (RCR)	(9) Responsible Conduct of Research Involving Human Subjects	Stony Brook Lecture Judy Matuk Lecture Readings: (Background Information, Case Studies, Helsinki Manuscript) Human Subjects handout Helsinki manuscript Discussion From Human Subjects handout, Case Study 1: Was this an ethical trial? If so, why? If not, why not? From Human Subjects handout, Case Study 2: Was this an ethical trial? If so, why? If not, why not? Why does the Helsinki Declaration limit the use of Placebo's? From Helsinki Manuscript: Do you agree with the authors that placebo-controlled trial are in many cases necessary ? Why ?
2015.04.15 Wed	Class discussion	Responsible Conduct of Research (RCR)	(10) Responsible Conduct of Research Involving Laboratory Animals	Stony Brook Lecture Tom Zimmerman Lecture Readings (Case Studies) Animal Subjects handout Discussion From Case Study 1: What are some of the troublesome issues associated with this set of experiments? From Case Study 1: Does giving an animal a fatal infection constitute cruelty, especially considering the characteristics of HIV infection in humans? From Case Study 1: Is it ethically appropriate to transmit intentionally a human virus in a setting that is not fully controlled? From Case Study 1: If Edith were to respond that the study could not be carried out in chimpanzees, how might it be designed instead for human subjects?
2015.04.22 Wed	Last name, First name	--	--	ROTATION/RESEARCH PRESENTATIONS
2015.04.29 Wed	Last name, First name	--	--	ROTATION/RESEARCH PRESENTATIONS
2015.05.06 Wed	Last name, First name	--	--	ROTATION/RESEARCH PRESENTATIONS